CANCER AND GENETICS
3 MOST COMMON CANCERS IN HONG KONG
Statistics from Hong Kong Cancer Registry, Hospital Authority. Last updated: Oct 2018
3,918 new cases
2,595 new cases
4,233 new cases
GENETIC CHANGES AND CANCER
division and survival
inhibits and suppresses
Inhibits cell death
Stimulates cell growth
Cells grow uncontrollably
THE 4 TYPES OF MUTATION
Insertion and deletion of 1kb in length of nucleotides into genomic data
SNV is a variation in a single nucleotide. It could also be explained as a point mutations, that result from errors during DNA replication or other types of damage to DNA
There are 4 types:
Copy Number Variant
Increase in the number of copies of a gene.
This could lead to an increase in RNA and proteins.
Hybrid gene formed from 2 previously separated gene. This occurs as a result of translocation/deletion/inversion.
Single nucleotide variants
Precision medicine is an approach for disease treatment and prevention that takes an individual's variability in genes, environment, and lifestyle into consideration.
This allows doctors and researchers to accurately predict the type of treatment and prevention strategies that would yield greatest effect for their patients.
The same type of cancer could be due to a completely different gene mutation in different patients. Through precision medicine, the analytical approach to determine the type of gene mutations can lead to targeted therapies.